Planning permission includes authorisation for the redevelopment of Stephenson Street, the former Parcelforce depot in West Ham.
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The scheme is set to be completed in four phases over the next 10 to 15 years and will include commercial and retail space, a new 1,000-pupil secondary school, two new parks, PRS homes and four buildings over 30 storeys.
The first phase of the development will deliver 1,000 of the new homes as well as a new entrance into West Ham tube station, two new pedestrian bridges, the first phase of the park and a new neighbourhood centre.
Berkeley was selected as the preferred development partner for the site by the GLA in 2015.